Research reveals that aerobic exercise can decrease fibrosis in aging skeletal muscles.

According to a recent research article published in the *Journal of Cachexia, Sarcopenia and Muscle*, Chinese researchers have discovered that aerobic exercise effectively reverses the decline in endurance capacity and mitigates muscle atrophy in aged mice.



 

Aging adversely affects tissue repair, particularly in skeletal muscles, where the regenerative capacity of muscle stem cells (MuSCs) diminishes over time. Although it is well-known that aerobic exercise can attenuate skeletal muscle atrophy, its specific impact on the regenerative and repair capacity of MuSCs had remained unclear. To investigate this, researchers from South China Normal University subjected mice to moderate-intensity continuous training (MICT) from either nine months to 25 months or 20 months to 25 months. They then evaluated the effects of aerobic exercise on MuSCs function and muscle regeneration.

 

The study's findings revealed that MICT initiated at both nine and 20 months led to a significant increase in running duration and distance. Furthermore, the exercise regimen resulted in increased skeletal muscle weight and an enhanced cross-sectional area.

 

One notable finding was that the secretion of connective tissue growth factor increases in the MuSCs aging process, which not only impairs the regenerative capacity of MuSCs but also leads to skeletal muscle fibrosis.

 

Aerobic exercise has demonstrated the capacity to reduce this harmful effect, suggesting that promoting aerobic exercise among the elderly could be beneficial.

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